Dr. Sayeed is a cell & molecular biologist with a particular focus on cancer biomarkers. His research interests are focused on the mechanisms of cancer progression and development of refractory states with a special emphasis on cellular signaling, metabolism, targeted therapeutics and microvesicles.

As a faculty at Thomas Jefferson University, Dr. Sayeed investigated underlying molecular mechanisms of radiation resistance using in vivo conditional transgenic model systems of prostate cancer and dissected the role of exosomes in prostate cancer progression.

Dr. Sayeed specialized in developing a battery of primary breast cancer model systems representing all histologic grades of the disease and investigated genetic signatures associated with cancer aggressiveness to discover and characterize novel molecular markers of aggressive disease during his tenure at California Pacific Medical Center in SFO. Dr. Sayeed conducted a pioneering study in establishing the molecular interaction between tumor suppressor p53 and estrogen receptor in breast cancer during his post-doctoral training at Roswell Park Cancer Institute. Overall, Dr. Sayeed has made conceptual advances in connecting signaling to gene expression to aggressive phenotypes and paved the way for new directions in biomedical research.