1. Determine the landscape of host and viral proteins associated with HBV DNA genome that are essential for HBV infection and maintenance, through labeling HBV DNA with a nucleoside analogue 5-ethynyl-2′-deoxyuridine (EdU) followed with a click-reaction for isolation of EdU labeled HBV DNA – protein complexes.

2. Assembly of HBV envelope proteins onto a reporter vesicular stomatitis virus (VSVs) pseudotype to identify host cellular factors involved in HBV entry through genome wide CRISPR screenings.

3. Selective elimination of HBV-infected hepatocytes through novel gene therapies