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Min Gao, PhD

Distinguished Professor

Biography

Training: Penn State (PH.D), Harvard medical school (post-Dr)
Research Overview: Min Gao is a virologist and has worked for Arbutus Biopharma and Bristol-Myers Squibb (BMS) company.  His group was focused on antiviral drug development and mode of inhibition.  His team was the first to successfully discover hepatitis C virus (HCV) NS5A replication complex inhibitors. This work led to the development of Daclatasvir (DCV) with unprecedented in vitro potency (pM to low nM) and remarkable clinical efficacy. Development of effective HCV combination therapy is one of the most successful stories in anti-viral therapy, whileNS5A inhibitor is an essential component of all interferon/ribavirin-free regimens in currently approved HCV therapies.

Research Projects: Herpes virus protease, HBV, HCV, Dengue virus, and SARS-CoV2 polymease

 

Publications

  • Liu F, Lee ACH, Guo F, ……Gao M. 2021. Host poly(A) polymerases PAPD5 and PAPD7 provide two layers of protection that ensure the integrity and stability of hepatitis B virus RNA. J Virologyhttps://doi.org/10.1128/JVI.00574-21
  • Sun JH, O’Boyle II DR, Fridell RA, .…., Gao M2015  Resensitizing Daclatasvir-Resistant Hepatitis C Variants by Allosteric Modulation of NS5A.  Nature 527:245-248.
  • Sun JH, O’ Boyle II DR, Zhang Y, Wang C, Nower PValera L, Roberts S, Nettles RE, Fridell RA, Gao M.  2011. Impact of a baseline polymorphism on the emergence of resistance to the HCV NS5A replication complex inhibitor BMS-790052. Hepatology55:1956-1965
  • Gao, M,Nettles, RE…., Hamann LG. 2010   A chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature465:96-100.
  • Robertson, B., P. J. McCann, W. W. Newcomb, J. C. Brown, R. J. Colonno, and M.Gao. 1996. Separate Functional Domains of the HSV-1 Protease: Evidence for Cleavage inside Capsids. J. Virol.70:4317-4328.

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